Fri Dec 09 2022

20 articles - From Friday Dec 02 2022 to Friday Dec 09 2022

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Arthritis Care Res (Hoboken)

Changes and associations between gait biomechanics and knee inflammation after aspiration and corticosteroid injection for knee osteoarthritis.

In patients with knee OA and synovitis, reduced inflammation and pain after aspiration and corticosteroid injection is associated with changes in knee gait biomechanics and strength.

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Sleep disturbance improves with SARS-COV2 vaccinations in patients with Chronic Inflammatory Disease.

Sleep disturbance decreased in a significant and meaningful way in patients with CID upon vaccination. In patients with higher baseline anxiety, social participation increased and anxiety, fatigue, and sleep disturbance decreased. Overall, results suggest that SARS-CoV-2 vaccines may improve mental health and wellbeing, particularly among those with greater anxiety.

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Arthritis Res Ther

Expression of CFTR, a hallmark gene of ionocytes, is downregulated in salivary glands of Sjögren's syndrome patients.

Those findings above proved an obviously downregulated expression of CFTR in salivary glands of SjS patients and its clinical significance. Dysfunction in CFTR or ionocytes may contribute to SjS pathogenesis and represents a promising therapeutic target.

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Inhibition of bone erosion, determined by high-resolution peripheral quantitative computed tomography (HR-pQCT), in rheumatoid arthritis patients receiving a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab vs csDMARD therapy alone: an open-label, randomized, parallel-group study.

Although the addition of denosumab to csDMARDs did not find statistically significant improvements in bone erosion after 6 months of treatment, numerical improvements in these parameters suggest that the addition of denosumab to csDMARDs may be effective in inhibiting the progression of bone erosion and improving bone micro-architecture.

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Arthritis Rheumatol

Amplification of inflammation by lubricin deficiency implicated in incident, erosive gout independent of hyperuricemia.

We linked normouricemic erosive gout to attenuated lubricin, with impaired control of Cathepsin G activity, compounded by deleterious NLRP3 variants. Lubricin suppressed monosodium urate crystallization, and blunted IL-1ß-induced increases in macrophage xanthine oxidase and urate. Collective activities of articular lubricin that could limit incident and erosive gouty arthritis independently of hyperuricemia are subject to disruption by inflammation, activated Cathepsin G, and synovial fibroblast TLR2 signaling.

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The characteristics of patients with COVID-19-associated pediatric vasculitis: an international, multicenter study.

This is the largest cohort of children with COVID-19 associated vasculitis (excluding MIS-C). Our findings suggest a more severe disease course in COVID-19-associated pediatric IgAV/HSP patients compared to pre-pandemic patients.

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Rheumatology (Oxford)

A novel estrogen receptor 1-sphingomyelin phosphodiesterase acid like 3B pathway mediates rituximab response in myositis patients.

In addition to B cell depletion, rituximab may be beneficial in myositis due to increased ESR1 signalling mediated by rituximab binding to SMPDL3B on skeletal muscle cells.

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Beneficial effects of nintedanib on cardiomyopathy in patients with systemic sclerosis: a pilot study.

Our data indicate beneficial signals of nintedanib on cardiomyopathy associated with SSc. The anti-fibrotic effect of nintedanib might not be limited to the lung.

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Crystalline silica exposure in patients with rheumatoid arthritis and systemic sclerosis: a nationwide cross-sectional survey.

The lifetime SiO2 exposure gap between RA and SSc patients and controls was substantially due to occupational exposure. In both diseases, men had higher exposure scores than women.

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Cumulative Disease Damage and Anti-PM/Scl Antibodies Are Associated with a Heavy Burden of Calcinosis in Systemic Sclerosis.

Calcinosis burden is associated with cumulative systemic sclerosis-related tissue damage. Independent of disease severity, autoantibodies to PM/Scl are also associated with a heavy burden of calcinosis.

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Non-Inflammatory Pain in Inflammatory Arthritis.

Lastly, we reviewed potential pathogenic mechanisms which included inflammatory cytokines sensitizing nociceptive neurones, temporal summation, also known as windup, from chronic pain and impaired coping from poor quality sleep and mental well-being. Deciphering the exact mechanisms may lead to treatment strategies that prevent development of secondary fibromyalgia and will address a common factor associated with difficult to treat RA.

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The association of trauma with self-reported flares and disease activity in systemic lupus erythematosus (SLE).

In this cohort, those with a history of trauma reported more flares and greater disease activity. Identifying mechanisms of associations between trauma and disease activity and flares, as well as interventions to mitigate the effects of trauma exposures is critical, given the high rates of trauma exposures.

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The natural history of chronic widespread pain in patients with axial spondyloarthritis: a cohort study with clinical and self-tracking data.

The development of CWP is predicted by higher levels of disease activity and burden at baseline. It also impacts future disease activity and wellbeing.

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The top 10 research priorities in psoriatic arthritis: a James Lind Alliance Priority Setting Partnership.

The top 10 priorities will guide PsA research and enable PsA researchers and those who fund research to know the most important questions for people living with PsA.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Arthritis Care Res (Hoboken)

Introduction to the Special Theme Issue: Heath Disparities and Health Equity in Rheumatic Diseases.

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Arthritis Rheumatol

TOCILIZUMAB IN GIANT CELL ARTERITIS: BETTER UNDERSTANDING THE BENEFITS.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Rheumatology (Oxford)

A novel frameshift variant in TNFRSF13B in a Chinese patient with late-onset combined immunodeficiency.

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Association between disability scores and opioid use in patients with psoriatic arthritis and ankylosing spondylitis.

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More to B: the growing evidence to inform targeting B cells in scleroderma.

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Letters&Replies

Letters to the editors and authors’ replies

Arthritis Care Res (Hoboken)

Fluorosis The settling toothpaste.

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